Samantha M. Mastanduno, DO

On the Upper East Side’s medical corridor, orthopedic surgery practices blend into the grid of specialty offices. Samantha M. Mastanduno, DO occupies the third floor of a Madison Avenue building, where the focus is purely on musculoskeletal care. This isn’t a walk-in clinic or a multi-specialty hub; the practice centers on surgical and non-surgical treatments for bones, joints, and connective tissues. Nearby, the stretch between 60th and 65th Streets hums with foot traffic, but inside, the work is precise and appointment-driven.

Orthopedic surgeons in Manhattan often cater to a mix of athletes, aging residents, and post-injury patients—this one is no exception. The address, 645 Madison Ave 3rd floor New York, NY 10022, places it steps from Central Park’s eastern edge, a detail that might matter to those recovering from procedures like ligament repairs or joint replacements. While the building itself is unassuming, the location offers easy access for patients coming from Midtown or the surrounding neighborhoods. Restroom facilities are available, a practical note for anyone arriving straight from physical therapy or a long commute.

Directions to the office are simplest via public transit or rideshare, given the area’s dense traffic patterns. A quick glance at the map confirms the proximity to the 68th Street-Hunter College subway station, a convenience for those relying on the 6 train. Parking, as with most of this zip code, tends to be a strategic endeavor—better planned in advance than left to chance.

Contact details are straightforward: calls can be directed to (212) 618-5900 for scheduling or questions. The practice doesn’t advertise extended evening hours or weekend slots, so weekday availability is likely the standard. In a city where orthopedic issues range from overuse injuries to age-related wear, having a specialized option on Madison Avenue—without the frills of a hospital campus—fits the neighborhood’s no-nonsense rhythm.