Irene Frantzis, MD

Upper Manhattan has its share of specialists, and when it comes to infectious diseases, Irene Frantzis, MD is one of the names that surfaces regularly. The practice sits at 3959 Broadway, a stretch of the city where the subway hums beneath sidewalks and bodegas keep long hours. Infectious disease physicians here often deal with everything from travel-related illnesses to chronic conditions that require careful monitoring.

Patients typically find themselves referred for a range of concerns—HIV management, hepatitis treatment, or unexplained fevers that resist initial diagnoses. The field itself demands precision, given how quickly infections can evolve. Those who walk into the office at Broadway and 165th Street are usually looking for answers that primary care hasn’t yet provided. It’s a quiet corner of medicine, but one that becomes essential when standard treatments fall short.

Directions are simple enough; the building is steps from the 1 train and a short walk from NewYork-Presbyterian’s main campus. For anyone needing to reach the office, (212) 305-4558 is the number to call. Appointments are generally scheduled through referrals, though the practice does accept new patients when capacity allows.

A map can be found here. If you’re heading up from Midtown, give yourself a few extra minutes—traffic on Broadway moves at its own pace.