Duane Reade

A quick stop for the essentials sits in a pocket of Midtown’s glass-and-steel grid. Duane Reade at 866 3rd Ave keeps basics within arm’s reach, whether you need a rush snack before the F train or a last-minute travel-size shampoo. Fresh coffee cups line the counter near the entrance, ready to wake you up at 6 a.m. or power a late-night dash to LaGuardia.

The convenience store stretches beyond cereal and soda aisles. Grab aspirin, a prepaid MetroCard mask refills when your apartment runs dry. Batteries and phone cables sit in the front rack, and a cooler behind the register offers chilled drinks for the walk south to 57th Street’s shops. Quick bites—protein bars, fruit cups—sit below the counter if you’re dodging tourists around Saks.

Place your call ahead to save time: (212) 759-9412. That single line connects you to stock questions—what’s in stock, what will be back tomorrow—without adding another stop on your route.

Direction cues are one click away. Pull up the map anytime you’re west of Park Avenue or north of 55th; the digital pin drops right on the doorstep: directions page loads fast even on subway Wi-Fi.