Diane M. Simeone, MD

Midtown East’s medical landscape is anchored by precise specialists—none more critical than surgical oncologists. That expertise lives on the 20th floor of 240 E 38th St. Diane M. Simeone, MD builds a practice around tumor removal, lymph node dissection, and advanced cancer surgeries. Many patients arrive expecting standard care only to find a practice comfortable with complex hepatobiliary and pancreatic resections.

Her office isn’t just another address on a block of polished glass towers. It shares the 20th floor with other specialty practices, making follow-up scans or consultations feel almost routine. Beyond the expected lumpectomies and mastectomies, you’ll find hyperthermic intraperitoneal chemotherapy and sentinel node mapping listed alongside standard biopsy follow-ups. The pace stays clinical: no waiting-room fluff, just appointments that start on time.

Reaching the practice takes seconds once you’re inside the building’s elevator bank. Call (212) 731-6150 for scheduling—no voicemail maze, just a direct line answered by someone who knows the protocols cold. They’ll confirm insurance, request imaging, and outline next steps before you even leave the lobby.

Directions are simple when the streets run straight east-west: hop off the 6 train at 38th or slide over on the Q. Pull up the map before you leave; the door is tucked between an insurance office and a financial firm, easy to miss if you blink.