Charles B. Simone, II, MD, FASTRO, FACRO

Oncology care in East Harlem just got a quiet upgrade. Charles B. Simone, II, MD, FASTRO, FACRO specializes in radiation treatment for cancers that require precision and patience. The practice sits at 225 E 126th St, a block where the neighborhood’s rhythm slows just enough to notice the details—like the way the sidewalk widens near the corner or how the morning light catches the brick facades. It’s the kind of setting where medical expertise feels less like a service and more like a necessary presence, one that blends into the daily life of the area without fanfare.

Patients here often arrive with questions about intensity-modulated radiation, stereotactic body radiotherapy, or proton therapy—terms that sound daunting until they’re explained in plain language. They handle cases from early-stage diagnoses to more complex scenarios, always with an eye on minimizing side effects. When it’s time to reach them, the number is (833) 697-7686. For directions, the map at this link will guide you past the bodegas and brownstones that define the stretch of 126th Street.